Research progress of purinergic signaling in dry age-related macular degeneration / 中华实验眼科杂志

ABSTRACT

Age-related macular degeneration (AMD) is one of the major causes of visual loss in people over 65 years of age.There is limited treatment for dry AMD, because of its complex mechanism.Purinergic signaling has the functions of signal transduction and neuro-modulation, participates in the development of dry AMD by regulating retinal cell death, microglial activity, inflammation, pathological deposit formation and retinal edema etc.In this study, we discussed the role and mechanisms involved in dry AMD by introducing the components of the purinergic signaling pathway, and further summarized the regulation of key processes in the pathogenesis of AMD in order to provide a reference for clinical research.