Effect of oat beta-glucans on blood levels of lipids, glucose and inflammatory factors in participants with hyperlipemia/hyperglycemia: an exploratory, prospective, single-center, randomized, double-blind, placebo-controlled study / 中华临床营养杂志

ABSTRACT

Objective:To investigate the impact of oat beta-glucans on blood levels of lipids, glucose, and inflammatory factors in patients with hyperlipemia/hyperglycemia.Methods:A total of 120 patients with hyperlipemia/hyperglycemia were randomized into intervention ( n = 60) and control groups ( n = 60). In addition to the routine nutritional consultation, two groups received oral oat beta-glucan at 3 g/d (intervention) or lotus root powder at 3 g/d (control), respectively. Blood levels of lipids, glucose, insulin and inflammatory factors, body composition and bowel movement were compared between the two groups after 12 weeks of study intervention. The treatment effect was represented by intention-to-treat analysis. Results:A total of 109 participants completed the study. The total cholesterol [(5.18±0.69) mmol/L vs (5.25±0.88) mmol/L, P=0.024] and fasting plasma glucose [(5.50±0.82) mmol/L vs (5.98±1.33) mmol/L, P=0.002] in the intervention group were significantly decreased compared with the control group. Conclusion:Oral oat beta-glucans could decrease the total cholesterol and fasting plasma glucose in participants with mild hyperlipemia/hyperglycemia.