Research progress of chronic insomnia and immune function / 中华神经科杂志

ABSTRACT

Chronic insomnia is a common sleep disorder in clinic. It is a frequent and persistent difficulty in sleep initiation, maintenance and termination, leading to different degrees of functional impairment during daytime awakening. Although its pathogenesis is still not completely clear, some people have proposed neurobiological and psychological models, and more and more people begin to pay attention to the study of immune factors and genetic factors. The immune system mainly includes immune organs, immune cells and immune molecules, which help organisms maintain their homeostasis and normal life activities. There are intricate relations between sleep and immune system. Chronic insomnia can affect the function of immune system, and immune disorder may in turn lead to chronic insomnia. This paper discusses the changes of immune system in patients with chronic insomnia, and the influence of immune system changes on patients with chronic insomnia, as well as the research progress of the correlation between chronic insomnia and immune function.