Research Progress on the Role of Mitochondrial DNA in the Pathogenesis of Chronic Liver Disease / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 447-451, 2022.
Article
Dans Chinois
| WPRIM
| ID: wpr-935965
ABSTRACT
Mitochondrial DNA is the mitochondria's own genetic material located within the mitochondrial matrix and is involved in cellular metabolism and energy supply. Mitochondrial DNA damage exacerbates oxidative stress by increasing the release of reactive oxygen species, while mitochondrial DNA release also triggers apoptosis and activates immune inflammatory responses through damage-related molecular patterns. Mitochondrial autophagy regulates mitochondrial DNA damage and release through a negative feedback mechanism to maintain intracellular homeostasis. Recent studies have shown that the occurrence and development of chronic liver disease are closely related to mitochondrial DNA-mediated immune inflammatory responses and oxidative stress.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Autophagie
/
ADN mitochondrial
/
Espèces réactives de l'oxygène
/
Apoptose
/
Stress oxydatif
/
Maladies du foie
/
Mitochondries
Type d'étude:
Etude d'étiologie
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2022
Type:
Article
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