Establishment of a live vaccine strain against fowl typhoid and paratyphoid / 대한수의학회지
Korean Journal of Veterinary Research
;
: 241-246, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-93659
ABSTRACT
To develop a live vaccine strain against fowl typhoid and paratyphoid caused by Salmonella serovar Gallinarum biovar Gallinarum (Salmonella Gallinarum) and Salmonella serovar Enteritidis (Salmonella Enteritidis), respectively, several nalidixic acid resistant mutants were selected from lipopolysaccharide (LPS) rough strains of Salmonella Gallinarum that escaped from fatal infection of a LPS-binding lytic bacteriophage. A non-virulent and immunogenic vaccine strain of Salmonella Gallinarum, SR2-N6, was established through in vivo pathogenicity and protection efficacy tests. SR2-N6 was highly protective against Salmonella Gallinarum and Salmonella Enteritidis and safer than Salmonella Gallinarum vaccine strain SG 9R in the condition of protein-energy malnutrition. Thus, SR2-N6 may be a safe and efficacious vaccine strain to prevent both fowl typhoid and paratyphoid.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Salmonella
/
Salmonella enteritidis
/
Bactériophages
/
Fièvre typhoïde
/
Nations Unies
/
Virulence
/
Acide nalidixique
/
Malnutrition protéinocalorique
langue:
Anglais
Texte intégral:
Korean Journal of Veterinary Research
Année:
2015
Type:
Article
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