Susceptibility gene polymorphisms of primary knee osteoarthritis: a systematic review / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 803-808, 2022.
Article
Dans Chinois
| WPRIM
| ID: wpr-939985
ABSTRACT
ObjectiveTo conduct a systematic review of the susceptibility gene polymorphism sites of primary knee osteoarthritis (PKO). MethodsThe literature on genetic susceptibility and gene polymorphisms of PKO were retrieved from PubMed, Web of Science, CNKI, Wanfang Data, and China Biomedical Literature Database from establishment of the library to December, 2020, and systematically reviewed. ResultsA total of 42 papers on the polymorphism sites of human PKO susceptibility genes were included, involving cellular signaling pathways related to PKO pathogenesis, including inflammatory response, receptor signaling pathway, transcription factor signaling pathway, bone-related signaling pathway, etc. Multiple gene polymorphism sites located in inflammatory factor genes, chemokine genes, Toll-like receptor genes, transcription factor genes, obesity-related genes, and bone-related genes. ConclusionInflammatory factor genes and bone-associated allele polymorphisms are likely to be related to PKO susceptibility.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Revues systématiques évaluées
langue:
Chinois
Texte intégral:
Chinese Journal of Rehabilitation Theory and Practice
Année:
2022
Type:
Article
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