Advances in basic and translational research in neuroendocrine neoplasms / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 867-874, 2021.
Article
Dans Chinois
| WPRIM
| ID: wpr-942984
ABSTRACT
With the development of diagnostic techniques and the improvement of people's living standards, the detection rate of neuroendocrine tumor has been increasing and people are paying more and more attention to it. With multiple treatment modalities, the clinical research progress of neuroendocrine tumor is remarkable. However, due to the tumor heterogeneity, metastasis and recurrence of neuroendocrine tumor remains a difficult problem for clinicians. The efficacy of neuroendocrine tumor still needs to be improved. Therefore, the biological behavior of neuroendocrine tumor needs to be further studied. In recent years, with the development of molecular biology, the basic and transformation research of neuroendocrine tumor has made some progress. In this paper, we focus on the hot topics of neuroendocrine tumor, such as multiomics (copy number variation, genomics, transcriptomics), tumor microenvironment (immune microenvironment, tumor microvasculature, tumor-associated fibroblasts, etc.), preclinical research model construction (cell lines, organoids, patient derived xenograft models, genetically engineered mice), etc. Specifically, the related clinical transformation significance will be elaborated.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs neuroendocrines
/
Variations de nombre de copies de segment d'ADN
/
/
Microenvironnement tumoral
/
Récidive tumorale locale
Type d'étude:
Guide de pratique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2021
Type:
Article
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