Is the Intensive Anticonvulsant Treatment for Control of Acute Posthypoxic Myoclonic Status Epilepticus Necessary?
Journal of the Korean Neurological Association
;
: 125-130, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-94511
ABSTRACT
BACKGROUND:
Acute posthypoxic myoclonic seizure is not an uncommon presentation in clinical practices. However, there have been only a few reports which include detailed description on the treatment of acute posthypoxic myoclonic status.METHODS:
We retrospectively analyzed the etiology, clinical course, nature and duration of myoclonus after hypoxic brain damage during a ten year period from 1992 to 2002. Patients who had possible explanations for myoclonic seizure other than hypoxic-ischemic events were excluded.RESULTS:
Eighty-two patients aged 24 to 81 years old were included in this study. All but 3 patients with pulmonary edema had a history of cardiorespiratory arrest caused by probable cardiogenic origin, acute asthma attack and upper airway obstruction. Ictal EEGs demonstrated intermittent generalized spike and polyspike activities or biPLEDs. Most patients died within a week and 6 patients remained in persistent vegetative states. The clinical outcome was not affected by the drug response of myoclonic status epilepticus or etiology of hypoxia.CONCLUSIONS:
Posthypoxic myoclonic status reflects severe and diffuse cortical damage, and implies a very poor prognosis. It may be a transient manifestation of severe cortical damage before massive and irreversible neocortical neuronal death, and aggressive anticonvulsant drug treatment would not be necessary in most patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Oedème pulmonaire
/
Asthme
/
Crises épileptiques
/
État de mal épileptique
/
Hypoxie cérébrale
/
Études rétrospectives
/
État végétatif persistant
/
Obstruction des voies aériennes
/
Électroencéphalographie
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Aged80
/
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Neurological Association
Année:
2006
Type:
Article
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