Effect of vitamin C and E on the lipid peroxide, antioxidant ability, and antioxidant vitamin levels in maternal and umbilical venous plasma / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 1117-1126, 2009.
Article
de Ko
| WPRIM
| ID: wpr-94827
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: This controlled trial investigated the effect of supplementation with vitamins C and E on the lipid peroxide, antioxidant ability, and antioxidant vitamin levels in full term maternal and umbilical venous plasma. METHODS: Forty pregnant women were randomized in this study. They were nulliparous or multiparous women with history of preeclampsia or preterm premature rupture of membranes (PPROM). Twenty women were given vitamin C (1,000 mg/day) and vitamin E (400 IU/day) from 15~20 gestational weeks to delivery. The others were not given, as a control group. Maternal venous blood was obtained before vitamin supplementation and just before delivery. Umbilical venous blood was obtained after delivery. Lipid peroxide level and oxygen-radical absorbance capacity (ORAC) were measured by thiobarbituric acid reaction and Cao's method, respectively. Ascorbic acid, uric acid, beta-carotene, retinol, alpha-tocopherol, and gamma-tocopherol were measured by high performance liquid chromatography. Results: Supplementation with vitamins C and E was associated with decrease in lipid peroxide levels and increase in ORAC values and alpha-tocopherol levels in maternal venous plasma. And it was also associated with decrease in lipid peroxide levels and increase in ORAC values and alpha-tocopherol levels in umbilical venous plasma. CONCLUSION: Supplementation with vitamins C and E may be beneficial in the prevention of oxidant-antioxidant imbalance origin diseases such as preeclampsia, PPROM. And it also may affect antioxidant ability of the fetus.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Plasma sanguin
/
Pré-éclampsie
/
Acide ascorbique
/
Rupture
/
Thiobarbituriques
/
Acide urique
/
Rétinol
/
Vitamine E
/
Vitamines
/
Bêtacarotène
Type d'étude:
Clinical_trials
Limites du sujet:
Female
/
Humans
langue:
Ko
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2009
Type:
Article