Antityrosinase, antioxidative activities, and brine shrimp lethality of ethanolic extracts from Protium serratum (Wall. ex Colebr.) Engl

ABSTRACT

Objective To evaluate all parts of Protium serratum (Wall. ex Colebr.) Engl. (P. serratum) for their phytochemistry and biological activities including antityrosinase, antioxidant, and brine shrimp lethality. Methods Nine ethanolic extracts from different P. serratum parts such as twig, whole fruit, pericarp, and root were investigated for their phytochemical screening and biological activities in terms of tyrosinase inhibition, antioxidant against 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals, and lethality to brine shrimp larvae. Results Phytochemical screening also revealed the presence of flavonoids, condensed tannins, alkaloids, triterpenoids, steroids, and sugars in P. serratum. The root extract was the most effective for antityrosinase activity with IC