Effects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats
Asian Pacific Journal of Tropical Biomedicine
;
(12): 829-833, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-950962
ABSTRACT
Objective:
To evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats.Methods:
Fourty-two rats were divided into 6 groups ( n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus.Results:
According to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (. P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased ( P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group ( P < 0.001).Conclusions:
The results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Asian Pacific Journal of Tropical Biomedicine
Année:
2015
Type:
Article
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