Expression of Fibroblast Growth Factor Receptor 3 in the Recurrence of Non-Muscle-Invasive Urothelial Carcinoma of the Bladder
Korean Journal of Urology
;
: 94-100, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-95244
ABSTRACT
PURPOSE:
The fibroblast growth factor receptor 3 (FGFR3) gene is known to be frequently mutated in noninvasive urothelial carcinomas of the bladder. In this study, we investigated the expression of FGFR3, Ki-67, and p53 in bladder cancers and the effects of expression on tumor recurrence. MATERIALS ANDMETHODS:
Fifty-five cases of primary bladder cancer were examined by immunohistochemistry. The relationship of these markers with various clinicopathological factors, including recurrence, was assessed.RESULTS:
Positivity for cytoplasmic FGFR3 (FGFR3-c) was associated with a lower cancer grade (p=0.022) and stage (p=0.011). Recurrence was more frequent in patients with a higher stage, negative FGFR3-c, and high Ki-67 expression. According to univariate analysis, predictors of recurrence-free survival included the following age, stage, FGFR-c, Ki-67, and p53. However, none of these was independent from the other parameters in multivariate studies.CONCLUSIONS:
The immunohistochemical expression of FGFR3 is not only one of the characteristic features of lower-grade and lower-stage urothelial carcinoma but also a possible marker in predicting disease recurrence.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
Vessie urinaire
/
Tumeurs de la vessie urinaire
/
Immunohistochimie
/
Carcinome transitionnel
/
Gènes p53
/
Récepteur facteur croissance fibroblaste
/
Cytoplasme
/
Récepteur de type 3 des facteurs de croissance fibroblastique
/
Facteurs de croissance fibroblastique
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Urology
Année:
2010
Type:
Article
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