Functional and binding studies of gallic acid showing platelet aggregation inhibitory effect as a thrombin inhibitor / 中草药·英文版
Chinese Herbal Medicines
;
(4): 303-309, 2022.
Article
Dans Chinois
| WPRIM
| ID: wpr-953589
ABSTRACT
Objective:
This study was devoted to identifying natural thrombin inhibitors from traditional Chinese medicine (TCM) and evaluating its biological activity in vitro and binding characteristics.Methods:
A combination strategy containing molecular docking, thrombin inhibition assay, surface plasmon resonance (SPR) and molecular dynamics simulation were applied to verify the study result.Results:
Gallic acid was confirmed as a direct thrombin inhibitor with IC
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Herbal Medicines
Année:
2022
Type:
Article
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