Role of IL-37 in childhood immune diseases / 国际儿科学杂志

ABSTRACT

Interleukin-37(IL-37)is an anti-inflammatory cytokine in the IL-1 family that suppresses both innate and adaptive immune responses in two ways intracellular complex formation and extracellular binding to membrane receptors.Studies have shown that IL-37 plays an important anti-inflammatory role in childhood immune diseases such as juvenile idiopathic arthritis, Kawasaki disease, inflammatory bowel disease, asthma, hand, foot and mouth disease and autism spectrum disease by regulating gene transcription, cell metabolism, cell proliferation and cytokine expression.This article reviews the biological characteristics, signaling pathway of IL-37 and its anti-inflammatory mechanism in childhood immune diseases.