Research progress in influences of epigenetic modifications on PD-L1 expression in tumors / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 345-348, 2022.
Article
Dans Chinois
| WPRIM
| ID: wpr-954287
ABSTRACT
Tumor cells expression of programmed death ligand-1 (PD-L1) is a major mechanism of immune escape and a predictor of therapeutic efficacy of immune checkpoint inhibitors. The expression of PD-L1 is regulated by a variety of mechanisms, among which epigenetic modifications such as DNA methylation, histone modification and non-coding RNA can promote the occurrence, development and drug resistance of tumors by regulating the expression of PD-L1. To clarify its regulation mechanism can bring new ideas for clinical immunotherapy of tumors.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of International Oncology
Année:
2022
Type:
Article
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