Research status and prospect on severe acute pancreatitis by mesenchymal stem cells treatment / 中华肝胆外科杂志

ABSTRACT

Severe acute pancreatitis progresses rapidly, with many complications and high mortality. Currently, the clinical treatment of severe acute pancreatitis is limited, so it is of great significance to control and treat the organ failure and long-term complications caused by severe acute pancreatitis. Mesenchymal stem cells play a beneficial role on severe acute pancreatitis therapy by promoting tissue regeneration, antioxidation, regulating autophagy and secreting anti-inflammatory factors. This paper summarized the current research status of mesenchymal stem cells on severe acute pancreatitis therapy and also showed the application of exosomes and the regulation of macrophage polarization, to provide new ideas and new targets for the treatment of severe acute pancreatitis.