Research progress on early diagnositic biomarkers of urinary sepsis / 中华泌尿外科杂志

ABSTRACT

The accuracy of the Sepsis-3 definition in the diagnosis of sepsis has been widely accepted and applied. Indicators such as Procalcitonin(PCT), white blood cell(WBC), C-reactive protein(CRP), platelets(PLT) and albumin are the most extensively and conveniently applied in early alert and diagnosis of urinary sepsis. PCT has a higher specificity and sensitivity compared to other biomarkers, and a sharp drop in WBC is a strong warning for septic shock. However, CRP has a relatively low specificity. IL-6, CD64, Presepsin, miRNA, and PTX-3, among others, are more valuable emerging indicators with higher sensitivity and specificity. However, uniform and standardized technology is necessary for a high quality testing. The combination of multiple biomarkers with a clinical scoring system is more useful than individual biomarkers clinically. This article mainly reviewed the progress of research on indicators related to early alert and diagnosis of urinary sepsis during recent years.