Progress in pathogenic mechanisms of neurotropic viruses crossing blood-brain barrier and invading central nervous system / 中华微生物学和免疫学杂志

ABSTRACT

Blood-brain barrier is a natural barrier between blood and brain tissue that can protect the brain from invasion by infectious pathogens in blood and maintain the homeostasis of the brain environment. However, neurotropic viruses can escape or disrupt blood-brain barrier and then invade the brain, causing serious complications in the central nervous system such as encephalitis and meningitis, which seriously threaten human life. This paper mainly summarized the research progress in the pathogenic mechanisms of common neurotropic viruses crossing blood-brain barrier and invading the central nervous system.