Anti-hemoptic drugs: I. Pitressin- a reinvestigation of its actions on the pulmonary circulation

ABSTRACT

1) In anesthetized artificially respiring dogs, Pituitrin causes a rise of systematic and fall of pulmonary pressure; Pitressin elicits a similar response to Pituitrin but the effects are relatively greater in degree2) A measured by a bubble flowmeter, Pitressin brings about decreased blood flow through the pulmonary circuit3) Lung perfusion experiments sustain the claim that Pitressin actually constricts the pulmonary vessels4) It is inferred from past and present experimental evidences that the pulmonary hypotension and the diminished pulmonary blood flow after Pitressin injection as attributable to depressed cardiac efficiency5) Our investigation give indication that Pitressin may enjoy widespread clinical use in the treatment of pulmonary hemorrhage, especially those cases attended with significant blood loss. (Summary and Conclusion)