Risk factors for recurrent papillary thyroid carcinoma
Philippine Journal of Otolaryngology Head and Neck Surgery
;
: 25-29, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-961023
ABSTRACT
@#<p style="text-align justify;"><strong>OBJECTIVE:
</strong> To identify risk factors associated with disease recurrence among Filipinos with papillary thyroid carcinoma (PTC).<br /><strong>METHODS:
</strong><br /><strong>Design:
</strong> Retrospective Cohort Study<br /><strong>Setting:
</strong> Tertiary National University Hospital<br /><strong>Participants:
</strong> 76 patients diagnosed with papillary thyroid carcinoma, classified as low and low-to-intermediate risk (2015 ATA classification) that underwent total thyroidectomy with or without neck dissection from 2010-2014 and were followed up from 10 months to 5 years. Log rank and Cox regression analyses were used to determine significant risk factors for recurrence.<br /><strong>RESULTS:
</strong> 29 (38.15%) had recurrence. On univariate analysis, age, tumor size, multifocality, extrathyroidal extension, presence of lateral neck nodes and RAI therapy were statistically associated with recurrence. However, on multivariate analysis, no clinicopathologic factor was statistically associated with recurrence.<br /><strong>CONCLUSION:
</strong> Age of >45 years, female sex, tumor size of >2 cm, multifocality, presence of microscopic extrathyroidal extension and lymph node metastasis might contribute to the recurrence of papillary thyroid cancer while post-operative radioactive ablation may have some protective effect. However, this study suggests that other factors must be included in the model to better understand the relationship between these factors and recurrence.</p>
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Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Évidement ganglionnaire cervical
/
Thyroïdectomie
/
Facteur IX
/
Tumeurs de la thyroïde
/
Analyse de régression
/
Cancer papillaire de la thyroïde
/
Noeuds lymphatiques
/
Métastase lymphatique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Philippine Journal of Otolaryngology Head and Neck Surgery
Année:
2017
Type:
Article
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