A case of acute drug-induced hepatotoxicity after albendazole treatment / 대한내과학회지
Korean Journal of Medicine
;
: 564-568, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-9622
ABSTRACT
Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazole-induced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aspartate aminotransferases
/
Autoanticorps
/
Benzimidazoles
/
Bilirubine
/
Marqueurs biologiques
/
Albendazole
/
Alanine transaminase
/
Lésions hépatiques dues aux substances
/
Foie
Limites du sujet:
Adulte
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
2008
Type:
Article
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