Effects of 2-methoxy 6-Chloro-9-Acridine in lepromatous leprosy

ABSTRACT

From this study, the effects of the three combinations namely 2-methoxy-6-chloro-9-acridine alone and 2-methoxy-6-choloro-9-acridine and DDS and DDS alone on the advanced cases of lepromatous type of leprosy confined at the Central Luzon Sanitarium- have been carefully evaluated. Our results have shown that 2-methoxy-6-choloro-9-acridine is more effective and very promising in the treatment of leprosy when given parenterally than by mouth. The explanation is that the parenteral 2-mthoxy-6-chloro-9-acridine can act as one molecule in the inhibition of the utilization of glycerol by the Mycobacterium leprae in contrast to the enteral 2-methoxy-6-chloro-9-acridine, which splits into the alkylamino radical and the acridine nucleus. On the other hand, this anti-metabolic action of 2-methoxy-6-chloro-9-acridine potentiated that of DDS when both are administered simultaneously. This is shown in the rapid regression of clinical signs and symptoms associated with the nagative bacteriological findings up to the time of this writing. Also, the lepra reactions have been controlled by prolonged treatment with parenteral 2-methoxy-6-chloro-9-acridineHowever, it is the strong opinion and recommendation of the researchers that though this is a controlled experiment, further study should be done for at most a period of five years in the different leper colony in the world. (Summary)