Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders / 소아과
Korean Journal of Pediatrics
;
: 420-424, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-96674
ABSTRACT
The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP, without any associated immunodeficiency. He had been EBV-seropositive for 8 years. The first clinical presentations were chronic respiratory symptoms and recurrent pneumonia. The symptoms worsened in the following 2 years. The results of in situ hybridization were positive for EBV, which led to a diagnosis of LIP. The diagnosis was confirmed by the results of a thoracoscopic lung biopsy. The EBV titer of the bronchoalveolar lavage specimens obtained after acyclovir treatment was found to be fluctuating. The patient had latent EBV infection for 8 years, until presented at the hospital with intermittent abdominal pain and distension. Physical examination and pelvic computed tomography revealed a large mesenteric mass. A biopsy of the excised mass led to a diagnosis of Burkitt's lymphoma (BL). The patient received combination chemotherapy for 4 months, consisting of vincristine, methotrexate, cyclophosphamide, doxorubicin, and prednisolone. He is now tumor-free, with the LIP under control, and is being followed-up at the outpatient clinic. This is the first report of a Korean case of chronic latent EBV infection that developed into LIP and BL in a nonimmunocompromised child.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Examen physique
/
Pneumopathie infectieuse
/
Vincristine
/
Biopsie
/
Aciclovir
/
Prednisolone
/
Lymphocytes B
/
Doxorubicine
/
Douleur abdominale
Type d'étude:
Etude diagnostique
Limites du sujet:
Adolescent
/
Enfant
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Korean Journal of Pediatrics
Année:
2014
Type:
Article
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