Photodynamic Therapy for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
Journal of the Korean Ophthalmological Society
;
: 789-798, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-9671
ABSTRACT
PURPOSE:
To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients.METHODS:
Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated.RESULTS:
244 patients (244 eyes) were recruited (male 60%, age 67.7+/-9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient.CONCLUSIONS:
Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Photothérapie dynamique
/
Pronostic
/
Acuité visuelle
/
Études de suivi
/
Choroïde
/
Néovascularisation choroïdienne
/
Corée
/
Dégénérescence maculaire
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Journal of the Korean Ophthalmological Society
Année:
2007
Type:
Article
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