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Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma
Journal of Pathology and Translational Medicine ; : 88-94, 2023.
Article Dans Anglais | WPRIM | ID: wpr-967647
ABSTRACT
Background@#Tumor-infiltrating neutrophils and lymphocytes play essential roles in promoting or combating various neoplasms. This study aimed to investigate the association between tumor-infiltrating neutrophils and lymphocytes and the neutrophil-to-lymphocyte ratio in the progression of urothelial carcinoma. @*Methods@#A total of 106 patients diagnosed with urothelial carcinoma were was. Pathological examination for tumor grade and stage and for tumor-infiltrating neutrophils, both CD4 and CD8+ T lymphocytes, as well as the neutrophil- to-lymphocyte ratio were evaluated. @*Results@#The presence of neutrophils and the neutrophil-to-lymphocyte ratio correlated with high-grade urothelial neoplasms. In both low- and high-grade tumors, the lymphocytes increased during progression from a non-invasive neoplasm to an early-invasive neoplasm. CD8+ T lymphocytes increased in low-grade non–muscle-invasive tumors compared to non-invasive tumors. Additionally, there was a significant decrease in CD8+ T lymphocytes during progression to muscle-invasive tumors. @*Conclusions@#Our results suggest that tumor-infiltrating neutrophils and CD8+ T lymphocytes have a significant effect on tumor grade and progression.
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Anglais Texte intégral: Journal of Pathology and Translational Medicine Année: 2023 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Anglais Texte intégral: Journal of Pathology and Translational Medicine Année: 2023 Type: Article