Therapeutic potential of targeting SIRT1 for the treatment of Alzheimer's disease / 生理学报
Acta Physiologica Sinica
;
(6): 99-107, 2023.
Article
Dans Chinois
| WPRIM
| ID: wpr-970110
ABSTRACT
Silent information regulator 1 (SIRT1) is one of the seven mammalian proteins of the sirtuin family of NAD+-dependent deacetylases. SIRT1 plays a pivotal role in neuroprotection and ongoing research has uncovered a mechanism by which SIRT1 may exert a neuroprotective effect on Alzheimer's disease (AD). Growing evidence demonstrates that SIRT1 regulates many pathological processes including amyloid-β precursor protein (APP) processing, neuroinflammation, neurodegeneration, and mitochondrial dysfunction. SIRT1 has recently received enormous attention, and pharmacological or transgenic approaches to activate the sirtuin pathway have shown promising results in the experimental models of AD. In the present review, we delineate the role of SIRT1 in AD from a disease-centered perspective and provides an up-to-date overview of the SIRT1 modulators and their potential as effective therapeutics in AD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Animal génétiquement modifié
/
Précurseur de la protéine bêta-amyloïde
/
Sirtuines
/
Sirtuine-1
/
Maladie d'Alzheimer
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2023
Type:
Article
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