Successful Allogeneic Hematopoietic Stem Cell Transplantation for a Patient with Very Severe Aplastic Anemia During Active Invasive Fungal Infection / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 57-60, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-97102
ABSTRACT
Allogeneic hematopoietic stem cell transplantation (HSCT) may not be considered feasible in a patient with active fungal infection due to transplant-related mortality. We report a case of HSCT performed on a 6-month-old girl, who was diagnosed with very severe aplastic anemia (vSAA) at the age of 2 months, during active invasive pulmonary aspergillosis (IPA). Despite receiving continuous antifungal treatment and multiple granulocyte infusions, her IPA was aggravated. She underwent allogeneic HSCT from a matched sibling donor using conditioning regimen of fludarabine, reduced dose of cyclophosphamide, and anti-thymocyte globulin (ATG) during IPA. After neutrophil engraftment, fever subsided and IPA improved. She was continued on voriconazole for 7 months after HSCT. She is alive with normal hematopoiesis 4 years post-transplant. Our report suggests that allogeneic HSCT using conditioning regimen of fludarabine, reduced dose of cyclophosphamide, and ATG can be a feasible option for the patients with vSAA even during active fungal infection.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Donneurs de tissus
/
Cellules souches hématopoïétiques
/
Mortalité
/
Transplantation de cellules souches hématopoïétiques
/
Cyclophosphamide
/
Fratrie
/
Aspergillose pulmonaire invasive
/
Fièvre
/
Granulocytes
/
Hématopoïèse
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Bébé
langue:
Anglais
Texte intégral:
Clinical Pediatric Hematology-Oncology
Année:
2016
Type:
Article
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