Research progress in Th17 cells and the relevant cytokines in Graves ' ophthalmopathy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1748-1753, 2022.
Article
Dans Anglais
| WPRIM
| ID: wpr-971360
ABSTRACT
Graves' ophthalmopathy is the most common clinical orbital disease, and T helper (Th) cells play an important role in the development of Graves' ophthalmopathy. Th17 cells are a major subpopulation of Th cells and abnormally highly expressed in patients with Graves' ophthalmopathy. Th17 cells and the related cytokines interleukin (IL)-17A, IL-21 and IL-23 are involved in regulating the inflammatory response, fibrosis and adipogenesis. Th17 cells are unstable and exhibit a degree of plasticity, and they can differentiate into IL-17A and interferon (IFN)-γ dual-producing Th17.1 cells, which exacerbate the pathogenicity of Th17 cells. In addition, Th17 cells and the relevant factors are strongly associated with disease activity and severity in Graves' ophthalmopathy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cytokines
/
Ophtalmopathie basedowienne
/
Adipogenèse
/
Cellules Th17
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2022
Type:
Article
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