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Development strategy and clinical research progress of universal chimeric antigen receptor T-cell drugs / 中国药科大学学报
Article de Zh | WPRIM | ID: wpr-972905
Bibliothèque responsable: WPRO
ABSTRACT
@#Chimeric antigen receptor T-cell (CAR-T) immunotherapy has made a breakthrough in the clinical treatment of a variety of hematological tumors.However, the CAR-T cell products listed at China and abroad are all autologous CAR-T.Compared with autologous CAR-T treatment, universal CAR-T exhibits significant advantages, which could fulfill the treatment demand of more patients, but also displays high technical barriers.This paper reviews the universal CAR-T, clearly points out the two major challenges faced by the development of universal CAR-T, and then summarizes and analyzes the feasible solutions according to the mechanism causing the two major problems.This paper also summarizes domestic and foreign companies producing universal CAR-T and the latest clinical progress of their superior products, and then discusses the feasibility of the development strategy from another aspect, in order to provide ideas for developing a new generation of universal CAR-T cell therapy products.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of China Pharmaceutical University Année: 2023 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of China Pharmaceutical University Année: 2023 Type: Article