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The key role of transcription factors on the innate immunity reaction / Эрүүл мэндийн лаборатори
Health Laboratory ; : 23-33, 2019.
Article Dans Anglais | WPRIM | ID: wpr-973028
ABSTRACT
Background@#The effect of lipopolysaccharide (LPS) on valproic acid (VPA)-induced cell death was examined by using mouse RAW 264.7 macrophage cells. @*Materials and methods, results@#LPS inhibited the activation of caspase 3 and poly (ADP-ribose) polymerase (PARP) and prevented VPA-induced apoptosis. LPS inhibited VPA-induced p53 activation and pifithrin-α as a p53 inhibitor as well as LPS prevented VPA-induced apoptosis. LPS abolished the increase of Bax/Bcl-2 ratio, which is a critical indicator of p53-mediated mitochondrial damage, in response to VPA. The nuclear factor (NF)-κB inhibitors, Bay 11-7082 and parthenolide, abolished the preventive action of LPS on VPA-induced apoptosis. A series of toll-like receptor (TLR) ligands, Pam3CSK4, poly IC, and CpG DNA as well as LPS prevented VPA-induced apoptosis. @*Conclusion@#Taken together, LPS was suggested to prevent VPA-induced apoptosis via activation of anti-apoptotic NF-κB and inhibition of pro-apoptotic p53 activation.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Anglais Texte intégral: Health Laboratory Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Anglais Texte intégral: Health Laboratory Année: 2019 Type: Article