Experimental Study for the Teratogenic Effect of Gamma-ray on the Heart of Chick Embryo
Journal of the Korean Pediatric Society
;
: 554-560, 2003.
Article
Dans Coréen
| WPRIM
| ID: wpr-97505
ABSTRACT
PURPOSE:
To investigate the teratogenic effect of gamma-ray on the heart of chick embryo.METHODS:
50 rad, 100 rad, 150 rad, 200 rad, 250 rad, and 300 rad of gamma-ray were used to irradiate three days old chick embryos. The control group was not irradiated. After three weeks, the embryos were sacrificed and examined for cardiovascular malformation.RESULTS:
The survival rate of the gamma-ray irradiated group was significantly lower than that of the control group(33.3-63.3% vs 76.4%, P=0.001). The cardiac malformation rate of the experimental group was 11.0%. In the control group, no congenital cardiac malformations were observed. The experimental groups had a significantly higher malformation rate(P=0.001). The types of malformation were ventricular septal defect, tricuspid atresia, Ebstein anomaly and aortic arch anomaly. In the gamma-ray irradiated group, the cardiac malformations were 14 small ventricular septal defects (VSDs), five large VSDs, two tricuspid atresias, and one Ebstein anomaly. The higher the dose of radiation applied, the higher the incidence of cardiac malformation was noted.CONCLUSION:
Gamma-ray irradiation of 3 days old chick embryos increased the rate of death and the rate of cardiac malformation significantly.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aorte thoracique
/
Incidence
/
Taux de survie
/
Atrésie tricuspide
/
Maladie d'Ebstein
/
Structures de l'embryon
/
Coeur
/
Communications interventriculaires
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Journal of the Korean Pediatric Society
Année:
2003
Type:
Article
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