Combination treatment of Umbilical Cord-derived Mesenchymal Stem Cell (UC-MSC) and Umbilical Cord Mesenchymal Stem Cell-derived Conditioned Medium (UCMSC-CM) for Keloid Post Chronic Burn Injury: A Case Report

ABSTRACT

@#A 44-years-old woman with hard and thick keloids after chronic mercury burn injury underwent a several times of reconstructive surgery. The patient had excised surgery and injected Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSCs) and Umbilical Cord Mesenchymal Stem Cells-derived Condtioned Medium (UCMSC-CM) 9 times within 9 months. Seven times injection of UC-MSCs of 5x106 cells and UCMSC-CM of 20 cc 2 times at months 4 and 9. The results of this therapy showed gradual improvement without any side effects and the size of the keloid reduced from 25x16 cm to 23x14 cm after 9 months. Keloid thickness from 12 mm to 4 mm. Keloid color becomes lighter and skin texture is more supple and soft. The cases showed that UC-MSCs and UCMSC-CM can be a potential treatment for keloids after chronic burn either alone or in combination with surgery.