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Scientific basis of acupuncture on mesenchymal stem cells for treating ischemic stroke / 中国针灸
Chinese Acupuncture & Moxibustion ; (12): 691-696, 2023.
Article Dans Chinois | WPRIM | ID: wpr-980780
ABSTRACT
The scientific basis of acupuncture on mesenchymal stem cells (MSCs) for treating ischemic stroke (IS) is discussed. MSCs transplantation has great potential for the treatment of tissue damage caused by early stage inflammatory cascade reactions of IS, but its actual transformation is limited by various factors. How to improve the homing efficiency of MSCs is the primary issue to enhance its efficacy. As such, the possible mechanisms of acupuncture and MSCs transplantation in inhibiting inflammatory cascade reactions induced by IS are explored by reviewing literature, and a hypothesis that acupuncture could promote the secretion of stromal cell-derived factor-1α (SDF-1α) from ischemic foci to regulate SDF-1α/CXC chemokine receptor 4 (CXCR4) axis, thereby improving the homing efficiency of MSCs transplantation, exerting its neuroprotective function, and improving the bed transformation ability, is proposed.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Thérapie par acupuncture / Chimiokine CXCL12 / Cellules souches mésenchymateuses / Accident vasculaire cérébral ischémique / Inflammation Limites du sujet: Humains langue: Chinois Texte intégral: Chinese Acupuncture & Moxibustion Année: 2023 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Thérapie par acupuncture / Chimiokine CXCL12 / Cellules souches mésenchymateuses / Accident vasculaire cérébral ischémique / Inflammation Limites du sujet: Humains langue: Chinois Texte intégral: Chinese Acupuncture & Moxibustion Année: 2023 Type: Article