A study on the relationship between the expression of apoptosis-related gene and the injury time in earlier period following cerebral contusion / 法医学杂志
Journal of Forensic Medicine
;
(6): 78-80, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-982975
ABSTRACT
OBJECTIVE@#To investigate the relationship between the expressive variety of apoptosis-related gene Bcl-2, Fas and the brain injury time during earlier period after cerebral contusion.@*METHODS@#The morphologia feature of brain tissue was observed under microscopy and immunohistochemistry, image analyze technique was applied to detected the expression of Bcl-2 and Fas.@*RESULTS@#Typical apoptotic cells were seen 8 hours after cerebral contusion. The expression of apoptosis-related gene was noted after 30 minutes and keep increase subsequently. The expression of Bcl-2 reached maximum level at 4 hours after brain trauma and then declined.@*CONCLUSION@#Detecting the expression of Bcl-2 and Fas would be of valuable in the distinguishment of promortem and postmortem injury, and the estimation of brain injury time during the earlier period after cerebral contusion.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs temps
/
Encéphale
/
Commotion de l'encéphale
/
Rat Wistar
/
Apoptose
/
Antigènes CD95
/
Protéines proto-oncogènes c-bcl-2
/
Médecine légale
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2003
Type:
Article
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