The study on the expression of caspase-3 in experimental brain contusion in rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 9-12, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-983007
ABSTRACT
OBJECTIVE@#To investigate the expression of caspase-3 in different posttraumatic intervals and severity of brain injury.@*METHODS@#The study examined brain tissue samples of slight (n = 24), severe (n = 24) brain injury and control (n = 6) of rat, using immunohistochemical staining, western-blot and RT-PCR method.@*RESULTS@#Up-regulating of caspase-3 expression was found in tissue from traumatic brain injury compared with controls in early 1 hour after TBI, and lasted for 14 days. The gray degree and threshold area of caspase-3 positive cells is different in different severity of brain injury.@*CONCLUSION@#The increasing of caspase-3 expression indicates that TBI exists. The gray degree, threshold area of caspase-3 positive cells and the cleavage degree of pro-caspase-3 have association with the severity of brain injury.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs temps
/
Lésions encéphaliques
/
ARN messager
/
Immunohistochimie
/
Technique de Western
/
Apoptose
/
Caspases
/
RT-PCR
/
Caspase-3
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2004
Type:
Article
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