Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt / 法医学杂志
Journal of Forensic Medicine
;
(6): 15-17, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-983119
ABSTRACT
OBJECTIVE@#To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.@*METHODS@#Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.@*RESULTS@#The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.@*CONCLUSION@#The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Mitochondries du foie
/
Extraits de plantes
/
Marqueurs biologiques
/
Répartition aléatoire
/
Magnoliopsida
/
Anatomopathologie légale
/
Relation dose-effet des médicaments
/
Réticulum endoplasmique
/
Rein
/
Dose létale 50
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2006
Type:
Article
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