Detection of gamma-hydroxybutyrate (GHB) in beverages / 法医学杂志
Journal of Forensic Medicine
;
(6): 120-129, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-983280
ABSTRACT
OBJECTIVE@#To establish an analytical method for the determination of GHB in beverages using GC/MS and LC/MS/MS.@*METHODS@#After beverage samples with GHB-d6 as the internal standard were extracted with ethyl acetate, then the extracts were derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), at last the derivateized extracts analyzed by gas chromatography- mass spectrometry. After beverage samples with GHB-d6 as the internal standard were diluted by mobile phase then directly analyzed by LC/MS/MS. Results The limit of detection was 0.2 microg/mL and both relative standard deviations for between-day and within-day assays were < 8.54% in GC/MS. The limit of detection was 2 microg/mL and both relative standard deviations for between-day and within-day assays were <8.62% in LC/MS/MS. Conclusion These methods of qualitative and quantitative analysis were found to be sensitive, accurate, rapid and suitable for the forensic toxicology to test of GHB in real cases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxybate de sodium
/
Boissons
/
Détection d'abus de substances
/
Reproductibilité des résultats
/
Sensibilité et spécificité
/
Anesthésiques intraveineux
/
Médecine légale
/
Concentration en ions d'hydrogène
/
Chromatographie gazeuse-spectrométrie de masse
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2007
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS