Changes of RyR2 mRNA expression in rats suffering from acute myocardial ischemia / 法医学杂志
Journal of Forensic Medicine
;
(6): 327-338, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-983403
ABSTRACT
OBJECTIVE@#To investigate the changes of ryanodine receptor 2 (RyR2) mRNA expression in rats suffering from acute myocardial ischemia.@*METHODS@#SD rats were divided randomly into normal control group, myocardial ischemia group and sudden death group. The models of myocardial ischemia and sudden cardiac death were induced by intraperitoneal injection of hypophysine. The changes of RyR2 mRNA expression in cardiac sarcoplasmic reticulum (SR) of rats suffering from myocardial ischemia were detected by fluorescent RT-PCR technique.@*RESULTS@#The levels of RyR2 mRNA in the myocardial ischemia group and sudden death group were significant lower than those in the control group (P<0.05).@*CONCLUSION@#Myocardial ischemia may induce down-regulation of cardiac SR RyR2 mRNA expression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Réticulum sarcoplasmique
/
ARN messager
/
Répartition aléatoire
/
Régulation négative
/
Mort subite cardiaque
/
Rat Sprague-Dawley
/
Ischémie myocardique
/
Canal de libération du calcium du récepteur à la ryanodine
/
RT-PCR
/
Anatomopathologie légale
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2008
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS