Expression of Fas protein in myocardiac tissue of viral myocarditis and dilated cardiomyopathy / 法医学杂志
Journal of Forensic Medicine
;
(6): 414-416, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-983418
ABSTRACT
OBJECTIVE@#To study the pathogenesis of viral myocarditis (VMC) and dilated cardiomyopathy (DCM) and their relationship.@*METHODS@#Sixty samples including 20 VMC, 20 DCM and 20 controls were collected. The expression of Fas protein in myocardium of each group was detected by modified immunohistochemistry with unequivocal brown staining in the myocardial membrane scored as positive, and the results of positive reaction were analyzed by Ridit test.@*RESULTS@#Fas protein expression increased obviously in VMC and DCM groups as compared with that of the control group. The difference of positive results between each group analyzed by Ridit test was statistically significant (P<0.005). Statistically significant differences were found between VMC and control groups as well as between DCM and control groups (P<0.05), but not between VMC and DCM groups (P>0.05) by multiple comparison Ridit test.@*CONCLUSION@#The expression of Fas protein is significantly higher in the VMC and DCM groups than in that of the control group. These results suggest that both the VMC and DCM may share a similar pathogenesis, which most likely involves cell apoptosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cardiomyopathie dilatée
/
Études cas-témoins
/
Apoptose
/
Antigènes CD95
/
Anatomopathologie légale
/
Myocardite
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2008
Type:
Article
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