Analysis and application of haplotype in forensic medicine / 法医学杂志
Journal of Forensic Medicine
;
(6): 133-137, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-983461
ABSTRACT
Haplotype is a lineable combination of alleles at multiple loci that are transmitted together on chromosome or mitochondrion. In October 2002, the international HapMap project started and aimed at mapping the haplotype blocks of human being and discovering the Tag SNPs by determining the DNA sequence variation patterns, variation frequency and their relationship. This review summarizes the formation and distribution of the haplotype and the current three haplotype-analysis methods including the methodology of experiment, the deduction from pedigrees and the statistic method. When an allele linkage disequilibrium occurs, the genetic probability would be evaluated by haplotype. The importance of haplotype has been recognized and its application has been gradually increased in forensic sciences. The current focus on haplotype study in forensic science involves Chromosome Y, Mitochondrial DNA and Chromosome X, which are useful supplements of genetic marks.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Haplotypes
/
ADN mitochondrial
/
Déséquilibre de liaison
/
Répétitions microsatellites
/
Polymorphisme de nucléotide simple
/
Chromosomes X humains
/
Chromosomes Y humains
/
Allèles
/
Génétique légale
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2009
Type:
Article
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