The value of TNFalpha testing in evaluation of death due to drug anaphylactic shock / 法医学杂志

ABSTRACT

OBJECTIVE@#To analyze the changes of the serum TNFalpha level in cadavers of drug anaphylactic shock(DAS) and to explore the significance of the TNFalpha testing in evaluation of death caused by DAS.@*METHODS@#The level of serum TNFalpha from cardiac blood was determined by double antibody-sandwich ELISA method.@*RESULTS@#The level of TNFalpha in the experimental group was (131.6+/-9.4) pg/mL, while the level in the infectious diseases control group and the normal control group were (87.3+/-6.4) pg/mL and (17.2+/-4.5) pg/mL, respectively. There was statistically significant difference among the groups (P<0.05).@*CONCLUSION@#The serum TNFalpha level may be used as one of the indexes for evaluation of death caused by highly suspected drug anaphylactic shock.