Advancement of methanol poisoning mechanism research / 法医学杂志
Journal of Forensic Medicine
;
(6): 294-296, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-983585
ABSTRACT
The methanol poisoning by oral intake or skin contact occurs occasionally, which may have serious consequences including blindness and/or death. Methanol and its metabolites, formaldehyde and formic acid, are associated with metabolic acidosis, visual dysfunction and neurological symptoms. At present, the mechanism of methanol poisoning primarily focuses on the cell hypoxia, the alteration of structure and biological activity induced by free radical and lactic acid. Meanwhile, methanol poisoning causes changes in the balance between the production of free radicals and antioxidant capacity and in the proteases-protease inhibitors system, which lead to a series of disturbances.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acidose
/
Troubles de la vision
/
Protéines
/
Méthanol
/
Formaldéhyde
/
Formiates
/
Radicaux libres
/
Oxidoreductases acting on CH-NH group donors
/
Système nerveux
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2010
Type:
Article
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