Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy / 法医学杂志
Journal of Forensic Medicine
;
(6): 328-331, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-983588
ABSTRACT
OBJECTIVE@#In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis (VMC) and dilated cardiomyopathy (DCM) were investigated.@*METHODS@#Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples, including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased.@*RESULTS@#The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group, which were statistically significant difference compared with control group (P < 0.05).@*CONCLUSION@#The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récepteurs viraux
/
Coloration et marquage
/
Immunohistochimie
/
Cardiomyopathie dilatée
/
Études cas-témoins
/
Mort subite cardiaque
/
Infections à virus coxsackie
/
Anatomopathologie légale
/
Protéine membranaire apparentée au récepteur des coxsackievirus et adénovirus
/
Myocardite
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2010
Type:
Article
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