Relationship between cholecystokinin gene -45C/T polymorphism and schizophrenia and its application in forensic medicine / 法医学杂志
Journal of Forensic Medicine
;
(6): 22-24, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-983619
ABSTRACT
OBJECTIVE@#To investigate the polymorphism of cholecystokinin (CCK) gene -45C/T of schizophrenia and its application in forensic medicine.@*METHODS@#Bidirectional allele specific PCR was used to detect CCK gene -45C/T polymorphisms in 207 schizophrenic patients (case group) and 202 healthy individuals (control group) of the Han population in northern China. The chi2 test was used to identify Hardy-Weinberg equilibrium of the genotype distribution in control group. The differences of genotype and allele frequencies distributions were compared between two groups.@*RESULTS@#Distributions of the genotype frequencies satisfied the law of Hardy-Weinberg equilibrium in control group. The differences between genotypic frequencies and allele frequencies were not statistical significance in case group and control groups (P > 0.05). Gender-stratified analysis showed that frequency of allele T in female case group was statistically higher than that in female control group (P = 0.044).@*CONCLUSION@#CCK gene -45C/T locus T allele may be positively associated with schizophrenia in female population and useful in schizophrenia identification.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Schizophrénie
/
Psychiatrie légale
/
Cholécystokinine
/
Études cas-témoins
/
Chine
/
Réaction de polymérisation en chaîne
/
Analyse de séquence d'ADN
/
Prédisposition génétique à une maladie
/
Asiatiques
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2011
Type:
Article
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