Time-dependent recruitment and differentiation of fibrocytes in mouse skin wound healing / 法医学杂志
Journal of Forensic Medicine
;
(6): 246-249, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-983657
ABSTRACT
OBJECTIVE@#To investigate the time-dependent recruitment and differentiation of fibrocytes in skin wound healing.@*METHODS@#Fibrocytes (expressing CD45 and procollagen I ) and myofibroblasts (expressing CD45 and alpha-SMA) were co-localized by immunofluorescent staining. The number of fibrocytes and myofibroblasts was counted at different post-wounding interval.@*RESULTS@#At 3 d after injury, fibrocytes started to recruit at the margin of the wounds. At 5 d after injury, myofibroblasts started to appear in new formed granulation tissue. The number of fibrocytes and myofibroblasts peaked at 7 d post-wounding.@*CONCLUSION@#During skin wound healing, myofibroblasts in granulation tissue originated at least partly from fibrocytic differentiation. The time-dependent recruitment and differentiation of fibrocytes may provide new information for wound age determination.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peau
/
Coloration et marquage
/
Facteurs temps
/
Cicatrisation de plaie
/
Numération cellulaire
/
Différenciation cellulaire
/
Antigènes CD45
/
Modèles animaux de maladie humaine
/
Myofibroblastes
/
Fibroblastes
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2011
Type:
Article
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