Effect of Stents Coated with Artemisinin or Dihydroartemisinin in a Porcine Coronary Restenosis Model
Korean Circulation Journal
;
: 115-122, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-98368
ABSTRACT
BACKGROUND AND OBJECTIVES:
Artemisinin and dihydroartemisinin are drugs used to treat malaria. These drugs suppress inflammatory reactions. The aim of this study was to examine the anti-intima hyperplasia effect of a novel drug-eluting stent with artemisinin or dihydroartemisinin in a porcine coronary restenosis model. MATERIALS ANDMETHODS:
Pigs were randomized into four groups; in the first, the coronary arteries (20 pigs, a total of 40 coronary arteries, with 10 coronary arteries in each group) was implanted with bare metal stents (BMS, n=10); the second group was given polymer-coated stents (PCS, n=10); the third group was treated with artemisinin-eluting stents (AES, n=10); and the fourth group was given dihydroartemisinin-eluting stents (DAES, n=10). Histopathologic analysis was performed 28 days after stenting.RESULTS:
The injury and fibrin scores among the four groups were not significantly different. However, the internal elastic lamina, lumen area, and neointima area were significantly different. Moreover, the percent area of stenosis (46.2±18.66% in BMS vs. 89.4±10.92% in PCS vs. 83.3±17.07% in AES vs. 36.7±11.20% in DAES, p<0.0001) and inflammation score (1.0 [range 1.0-1.0] vs. 3.0 [range 2.25-3.0] vs. 3.0 [range 1.0-3.0] vs. 2.0 [range 1.75-3.0] in BMS, PCS, AES, and DAES, respectively; p<0.001) were markedly decreased in the DAES group compared to the PCS group.CONCLUSION:
DES, which uses a natural substance, dihydroartemisinin, showed a neointima and inflammatory suppressive effect in a porcine coronary restenosis model.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Suidae
/
Fibrine
/
Endoprothèses
/
Sténose pathologique
/
Vaisseaux coronaires
/
Resténose coronaire
/
Endoprothèses à élution de substances
/
Néointima
/
Hyperplasie
/
Inflammation
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Texte intégral:
Korean Circulation Journal
Année:
2017
Type:
Article
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