Magnetic resonance diffusion tensor imaging for diagnosis of pyramidal tract damage in rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 256-268, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-983744
ABSTRACT
OBJECTIVE@#To explore the applicability of magnetic resonance diffusion tensor imaging (DTI) for diagnosis of pyramidal tract damage in rats.@*METHODS@#Marmarou's model was set up, followed by DTI scanning at 3, 12, 24 and 72 h post trauma to acquire the dispersion parameter of bilateral pyramidal tracts. Moreover, axonal varicosities per square millimeter and the percentage of positive area of axons demonstrated by beta-amyloid precursor protein (beta-APP) immunostaining were obtained, as well as the mean density and sum density of neurofilament (NF) 68 immunostaining.@*RESULTS@#Axial diffusivity (AD), fraction anisotropy (FA) and relative anisotropy (RA) in the pyramidal tract were significantly and continuously reduced and reached to the bottom at 72h post trauma (P < 0.05) in accord with the gradient of axonal damage verified by beta-APP and NF68 immunostaining. Furthermore, the changes of AD, FA and RA showed a significant negative correlation with the beta-APP immunohistochemical results.@*CONCLUSION@#DTI has important value for early diagnosis in pyramidal tract damage.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tractus pyramidaux
/
Axones
/
Facteurs temps
/
Indice de gravité de la maladie
/
Traitement d'image par ordinateur
/
Encéphale
/
Lésions encéphaliques
/
Protéines neurofilamenteuses
/
Anisotropie
/
Précurseur de la protéine bêta-amyloïde
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2012
Type:
Article
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