Genetic polymorphisms of 18 STR loci in Uygur population of Kashi Prefecture of Xinjiang / 法医学杂志
Journal of Forensic Medicine
;
(6): 451-455, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-983780
ABSTRACT
OBJECTIVE@#To investigate the genetic polymorphisms of 18 STR loci (D18S51, D21S11, D3S1358, FGA, D8S1179, upsilonWA, CSF1PO, D16S539, D7S820, D13S317, D5S818, D2S1338, D19S433, D12S391, TPOX, TH01, Penta E and D6S1043) in unrelated Uygur individuals in Kashi prefecture of Xinjiang and to explore the application value in forensic practice.@*METHODS@#Blood samples from 1 381 unrelated Uygur individuals were amplified by using DNA Typer 15 Plus kit. The amplified products were detected by using 3130XL Genetic Analyzer and the genotyping was done by using GeneMapper ID v3.2. Population genetics parameters were calculated and compared with that of the other population. The genetic distance of Reynold's was calculated and phylogenetic tree was constructed at last.@*RESULTS@#Of the 1 381 unrelated Uygur individuals, 231 alleles were detected, with an allele frequency of 0.0004-0.5304. The H values were 0.644-0.923, PIC values were 0.587-0.918, and DP values were 0.817-0.988, respectively, with a CPE > 0.9999999. The genetic distance was the longest (0.088 3) to Guangzhou Han population and the closest (0.0503) to Greek.@*CONCLUSION@#The 18 STR loci in the Uygur population of Kashi prefecture of Xinjiang have high genetic polymorphisms which are close to Europeans, and can be satisfied as genetic markers of population individual identification and paternity testing.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Chine
/
Réaction de polymérisation en chaîne
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Répétitions microsatellites
/
Asiatiques
/
Génétique légale
/
Locus génétiques
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Fréquence d'allèle
/
Génétique des populations
/
Génotype
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2012
Type:
Article
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