Gene detection of GPD1-L and the association with sudden unexplained death syndrome in young adults / 法医学杂志
Journal of Forensic Medicine
;
(6): 348-352, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-983849
ABSTRACT
OBJECTIVE@#To analyze the variations of glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) and address the association with sudden manhood death syndrome (SMDS).@*METHODS@#The genomic DNA was extracted from blood samples of the SMDS group and the normal control group. The exons, exon-intron boundaries and 3'-UTRs of coding region of GPD1-L were PCR amplified and DNA sequenced directly to confirm the types of variations. The genotype frequency and allele frequency were analyzed statistically.@*RESULTS@#There were two variants in the SMDS group, c.465C>T and c.*18G>T, the latter existed certain degree difference of genotype distribution and allele frequency between the SMDS group and the control group, but there was no statistically significant (P > 0.05).@*CONCLUSION@#The relation between gene mutation of GPD1-L and the occurrence of Chinese SMDS deserves a further research.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Analyse de mutations d'ADN
/
Séquence nucléotidique
/
Études cas-témoins
/
Réaction de polymérisation en chaîne
/
Exons
/
Amorces ADN
/
Polymorphisme de nucléotide simple
/
Mort subite
/
Asiatiques
/
Fréquence d'allèle
Limites du sujet:
Adolescent
/
Adulte
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2013
Type:
Article
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