Expression of Aquaporin 4 in Diffuse Brain Injury of Rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 18-25, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-984035
ABSTRACT
OBJECTIVE@#To observe the expression of aquaporin 4 (AQP4) in diffuse brain injury (DBI) of rats and to explore the corresponding effect of AQP4 for brain edema.@*METHODS@#The rat model of DBI was established using Marmarou's impact-compression trauma model. Brain water content was measured by dry-wet weight method. Blood-brain barrier permeability was evaluated by Evans blue (EB) staining. Immunohistochemical method was used to observe the expression of AQP4.@*RESULTS@#Brain water content increased after 3 h and peaked at 24 h after DBI. Brain EB content significantly increased and peaked at 12 h after DBI. The expression of AQP4 significantly increased after 3 h and peaked at 24 h after DBI, and the number of AQP4 positive astrocytes increased.@*CONCLUSION@#The increment of the permeability of blood-brain barrier and the expression of AQP4 may contribute to the development of brain edema in rat DBI. The change of AQP4 expression in astrocytes may also contribute to determine DBI.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Perméabilité
/
Encéphale
/
Oedème cérébral
/
Lésions encéphaliques
/
Eau
/
Barrière hémato-encéphalique
/
Perméabilité des membranes cellulaires
/
Astrocytes
/
Modèles animaux de maladie humaine
/
Aquaporine-4
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Forensic Medicine
Année:
2016
Type:
Article
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